Physiological Insulin Resistance

Petro Dobromylskyj is the founder of this idea that the way to stop fat cells from growing is to make them insulin resistant. Aka make them stop responding to insulin in terms of how the cells release fatty acids and how they take up glucose.

This idea became the Reactive Oxygen Species (ROS) theory of obesity. The theory revolves around how many reactive oxygen species and hydroxides are being produced by the mitochondria. Long Chain Saturated Fats (LCSF) produce lots of these which cause a slow down at complex 1 in the electron transport chain in the mitochondria. The slow down causes reverse electron transport causing hydrogen ions to be pushed back out causing the cell to expel energy as heat and signaling for the cell to become insulin resistant. Insulin resistant the cell now won't accept glucose from the insulin transporter and will stop the release of fatty acids into the blood for a much shorter period of time.

What does this mean:

• The amount of energy able to insert itself into the cell is now reduced which allows fat cells to burn through their own fat stores rather than have to burn substances which are coming in.

• Other organs and tissues now have more glucose available for longer allowing them to utilise glucose. Insulin resistant fat cells do not mean insulin resistant muscle cells.

• Fat cells are able to more readily release fatty acids into the blood stream to be used as fuel .

This theory works best with LCSF and Petro shows by analysing others peoples work that Polyunsaturated Fatty Acids (PUFA) keeps fat cells insulin sensitive. Aka fat cells continue to try to take in glucose and will not release free fatty acids as readily when required.

Recent work by Petro has identified that short chain saturated fatty acids and medium chain saturated fatty acids may also be an issue. The reason is they are shown on their own to be insulin sensitising. I will write more on this in the future.

To put it simply LCSF causes fat cells to become insulin resistant increasing their ability to release free fatty acids and limit energy coming in to them. This leads to less hunger and slower gain of weight.

References:

Medium chain triglycerides - https://high-fat-nutrition.blogspot.com/2023/03/how-can-insulin-resistance-cause-weight.html

Short chain fatty acity - https://high-fat-nutrition.blogspot.com/2021/12/protons-67-formula-revised-for-butter.html

https://high-fat-nutrition.blogspot.com/2019/12/protons-52-correction-and-few-thoughts.html